Glucose tolerance and blood pressure are improved in the spontaneously hypertensive rat by ethyl-2-(6-(4-chlorophenoxy)-hexyl) oxirane-2-carboxylate (etomoxir), an inhibitor of fatty acid oxidation. Am J Hypertens. 1994; 7:739–744. [PubMed: 7986465

We have demonstrated that glucose tolerance and insulin action are impaired in the spontaneously hypertensive rat (SHR), and that free fatty acids are elevated. Etomoxir, an inhibitor of fatty acid oxidation, has been shown to improve hyperglyce-mia in diabetic rats. We therefore performed oral glucose tolerance tests in SHR to assess glucose tolerance and insulin action in response to eto-moxir. Because of the proposed relation between insulin action and hypertension, we examined the effect of etomoxir on blood pressure. Thirteen-week-old male SHR were randomized into two groups. Food was withdrawn at 8 AM and at 11 AM, animals received etomoxir (50 mg/kg) or control vehicle by gavage. Oral glucose toleranc