Host Single-Nucleotide Polymorphisms and Altered Responses to Inactivated Influenza Vaccine

We analyzed the relationship between host gene polymor-phisms and responses in recipients of inactivated influenza vaccine, who were classified into poor, normal, or adverse response groups. The frequency of the mannose-binding lec-tin–2 codon 54 allele was significantly different among the 3 types of responders, with a decreased odds ratio for the development of poor or adverse responses (). TherePp.033 was no statistical relationship between responses and either tumor necrosis factor–a or interleukin (IL)–10 promoter polymorphisms among the 3 response groups. When poor and normal responses were combined, the 1082 A allele in the IL-10 promoter conferred a significantly decreased risk of the development of adverse responses (). ThesePp.041 data indicate that host polymorphisms play a role in deter-mining responses to influenza vaccine