How I treat How I treat the antiphospholipid syndrome

This article discusses how we approach medical decision making in the treatment of the various facets of the antiphospho-lipid syndrome (APS), including second-ary prophylaxis in the setting of venous and arterial thrombosis, as well as treat-ment for the prevention of recurrent mis-carriages and fetal death. The role of primary thromboprophylaxis is also dis-cussed in depth. Great emphasis is given to incorporating the most up-to-date and relevant evidence base both from the APS literature, and from large, recent, random-ized controlled trials (RCTs) of primary and secondary thrombotic prophylaxis in the general population setting (ie, the population that has not been specifically investigated for APS). (Blood. 2009;114: 2020-2030