Effects of Mannose-Binding Lectin Polymorphisms on

The content of this article has been reviewed by independent peer reviewers to ensure that it is balanced, objective, and free from commercial bias. No financial relationships relevant to the content of this article have been disclosed by the independent peer reviewers. Objective. Mannose-binding lectin (MBL) is important in the innate immune response. MBL2 gene polymor-phisms affect MBL expression, and genotypes yielding low MBL levels have been associated with an elevated risk for infections in hematological cancer patients un-dergoing chemotherapy. However, these reported asso-ciations are inconsistent, and data on patients with solid tumors are lacking. Here, we investigated the effects of MBL2 genotypes on irinotecan-induced febrile neutro-penia in patients with solid tumors. Patients and Methods. Irinotecan-treated patient