Evidence implicating a tRNA heritage for the promoters of positive-strand RNA synthesis in brome mosaic virus and related viruses

Many animal viruses, and the majority of plant vi-ruses, have an RNA-based genome. Far less is known about molecular mechanisms of replication for these viruses than is the case for viruses having a DNA genome, one reason being that RNA-based genomes have been inherently less amenable to experimental manipulation. Recently, however, considerable strides have been made in understanding this process at the molecular level for brome mosaic virus (BMV), whic