Rationale: Human embryonic stem cells can form cardiomyocytes when cultured under differentiation conditions. Although the initiating step of mesoderm formation is well characterized, the subsequent steps that promote for cardiac lineages are poorly understood and limit the yield of cardiomyocytes. Objective: Our aim was to develop a human embryonic stem cell–based high-content screening assay to discover small molecules that drive cardiogenic differentiation after mesoderm is established to improve our understand-ing of the biology involved. Screening of libraries of small-molecule pathway modulators was predicted to provide insight into the cellular proteins and signaling pathways that control stem cell cardiogenesis. Methods and Results:...
Human embryonic stem cell-based high-content screening of 550 known signal transduction modulators s...
The Notch signaling pathway plays versatile roles during heart development. However, there is contra...
Human pluripotent stem cells derived cardiomyoctyes are one the most promising cells for cardiac res...
SummaryWe have developed a robust in vivo small-molecule screen that modulates heart size and cardio...
SummaryHuman pluripotent stem cells (hPSCs), including embryonic stem cells and induced pluripotent ...
Human pluripotent stem cells (hPSCs), including embryonic stem cells and induced pluripotent stem ce...
Heart diseases are leading cause of death around the world. Given their unique capacity to self-rene...
Human pluripotent stem cells (hPSCs), including embryonic stem cells and induced pluripotent stem ce...
SummaryWnt signaling is a key regulator of vertebrate heart development; however, specific roles for...
Cardiovascular diseases contribute a large amount of morbidity and mortality in developing and devel...
The controlled differentiation of embryonic stem cells into specific cell types holds promise for ce...
Funding: A Münsterberg acknowledges research grant funding from BHF (PG/15/77/31761) and BBSRC (BB/N...
AbstractCardiomyocytes (CMs) derived from human pluripotent stem cells (hPSCs) offer immense value i...
BACKGROUND:Pluripotent embryonic stem (ES) cells, which have the capacity to give rise to all tissue...
Embryonic stem cells (ESCs) represent a promising source of cells for cell replacement therapy in th...
Human embryonic stem cell-based high-content screening of 550 known signal transduction modulators s...
The Notch signaling pathway plays versatile roles during heart development. However, there is contra...
Human pluripotent stem cells derived cardiomyoctyes are one the most promising cells for cardiac res...
SummaryWe have developed a robust in vivo small-molecule screen that modulates heart size and cardio...
SummaryHuman pluripotent stem cells (hPSCs), including embryonic stem cells and induced pluripotent ...
Human pluripotent stem cells (hPSCs), including embryonic stem cells and induced pluripotent stem ce...
Heart diseases are leading cause of death around the world. Given their unique capacity to self-rene...
Human pluripotent stem cells (hPSCs), including embryonic stem cells and induced pluripotent stem ce...
SummaryWnt signaling is a key regulator of vertebrate heart development; however, specific roles for...
Cardiovascular diseases contribute a large amount of morbidity and mortality in developing and devel...
The controlled differentiation of embryonic stem cells into specific cell types holds promise for ce...
Funding: A Münsterberg acknowledges research grant funding from BHF (PG/15/77/31761) and BBSRC (BB/N...
AbstractCardiomyocytes (CMs) derived from human pluripotent stem cells (hPSCs) offer immense value i...
BACKGROUND:Pluripotent embryonic stem (ES) cells, which have the capacity to give rise to all tissue...
Embryonic stem cells (ESCs) represent a promising source of cells for cell replacement therapy in th...
Human embryonic stem cell-based high-content screening of 550 known signal transduction modulators s...
The Notch signaling pathway plays versatile roles during heart development. However, there is contra...
Human pluripotent stem cells derived cardiomyoctyes are one the most promising cells for cardiac res...