BACTERIOLOGIC STUPIES OF EXPERIMENTAL SALMONELLA INFECTIONS IN CHICKS

fect man and animals with the produc-tion of disorders which range from trivi-al to fulminating in their manifestations. Such infections, though frequent and world wide in their distribution, are not adequately controlled by current preventive measures or available chemo-therapeutic agents. Consequently, the relative importance of salmonellosis as a public health problem is increasing. In this country human salmonellosis is predominantly an enteric infection with a nonfatal outcome. In attempting to study the disease experimentally it would be highly desirable to be able to work with an infectious process of com-parable clinicopathologic course. In the laboratory, however, attempts to pro-duce experimental infections through deliberate exposure to cultured bacteria are often surprisingly unsuccessful de-spite the fact that an extremely wide range of animal hosts has been found to harbor these infections in nature and although spontaneously occurring salmonellosis frequently produces epi-Received for publication June 25, 1951. This investigation was supported by the Offic