Cancer Immun Cancer Immunity

tion antigens represen ins and carbohydrates tha Downloaded from on March 5, 2016. © 2012 American Assoccancerimmunolres.aacrjournals.org t a diverse group of t are found on the surface of serological investigation of cancer with the emergence of the cytotoxic test as a powerful tool to analyze the cell surface reactivity of alloantibodies. This subsequently led to the recognition that the cell surface is a highly differentiated structure. During the 1960s and 1970s, Lloyd Old made a series toxins into the cancer cell and for antibodies whose action is primarily based on downregulation of cell surface receptors (2). Tumor-associated antigens recognized by therapeutic mAbs are outlined in Table 1. Hematopoietic differentiation antigens are glycoproteins usually associated with CD groupings and Cancer serology- the prelude to antibody therapeutics The concept that antibodies could serve as ‘magic bullets ’ i