Glycemic Targets in the Second and Third Trimester of Pregnancy for Women With Type 1 Diabetes DOI: 10.2337/dc14-1755 OBJECTIVE

To assess the relationship between second and third trimester glycemic control and adverse outcomes in pregnant women with type 1 diabetes, as uncertainty exists about optimum glycemic targets. RESEARCH DESIGN AND METHODS Pregnancy outcomes were assessed prospectively in 725 women with type 1 di-abetes from theDiabetes and Pre-eclampsia Intervention Trial. HbA1c (A1C) values at 26 and 34weeks ’ gestationwere categorized into five groups, the lowest, <6.0% (42 mmol/mol), being the reference. Average pre- and postprandial results from an eight-point capillary glucose profile the previous day were categorized into five groups, the lowest (preprandial <5.0 mmol/L and postprandial <6.0 mmol/L) being the reference. RESULTS An A1C of 6.0–6.4 % (42–47 mmol/mol) at 26 weeks ’ gestation was associated with a significantly increased risk of large for gestational age (LGA) (odds ratio 1.7 [95 % CI 1.0–3.0]) and an A1C of 6.5–6.9 % (48–52 mmol/mol) with a signifi