Effects of lipid administration on lymphatic apolipoprotein A-IV and B output and synthesis

lymphatic apolipoprotein A-IV and B output and synthesis. Am. J. Physiol. 271 (Gastrointest. Liver Physiol. 34): G322-G329, 1996.-We examined the mesenteric lymphatic and portal venous transport of triglyceride (TG), free fatty acids (FFA), apolipoproteins (ape) A-IV and B in response to a bolus duodenal infusion of a TG-free control solution, and long-chain (l&l) and medium-chain (8:O) TG (LCT and MCT, respectively) emulsions in the rat. Additionally, intestinal and hepatic apo A-IV and apo B mRNA levels were also measured. Lymph apo A-IV, apo B (B-48), FFA, and TG output increased after LCT infusion, whereas only apo A-IV and FFA outputs increased after MCT infusion. On the other hand, portal FFA and apo A-IV transports increased at 15 min after MCT infusion but not after LCT infusion. Portal TG and apo B transports were not altered by either MCT or LCT infusion