REVIEW ARTICLE Clinical applications of pharmacogenomics guided warfarin dosing

Abstract Aim of the Review To assess the state of the literature concerning pharmacogenomic testing in patients requiring vitamin K antagonists, specifically warfarin. Method We conducted a literature search of MEDLINE and International Pharmaceutical Abstracts using the fol-lowing words: warfarin, pharmacogenetic, and pharmac-ogenomic. The search results were reviewed by the authors and papers concerning pharmacogenomic testing in war-farin dosing were procured and reviewed. Additionally bibliographies of papers procured were also examined for other studies. The authors focused on clinical trials con-cerning the use of pharmacogenomic testing in warfarin dosing. Results Although numerous studies have demon-strated that a significant portion of warfarin dosing vari-ability can be explained by genetic polymorphisms, fe