This study was conducted to determine whether Pneumocystis carinii dyhydropteroate syn-thase (DHPS) gene mutations in AIDS patients with P. carinii pneumonia (PCP) are affected by duration of sulfa or sulfone prophylaxis and in¯uence response to sulfa or sulfone therapy. The P. carinii DHPS genes from 97 AIDS patients with PCP between 1991 and 1999 from 4 medical centers were ampli®ed, using polymerase chain reaction (PCR), and sequenced. Mu-tations were observed in 76 % of isolates from patients exposed to sulfa or sulfone prophylaxis compared with 23 % of isolates from patients not exposed (). Duration of prophylaxisP p.001 increased the risk of mutations (relative risk [RR] for each exposure month, 1.06;).P p.02 Twenty-eight percent of p...
Mutations in the dihydropteroate synthase (DHPS) gene of Pneumocystis jirovecii are associated with ...
Pneumocystis jirovecii dihydropteroate synthase (DHPS) mutations have been associated with failure o...
Pneumocystis jirovecii is a major opportunistic pathogen that causes Pneumocystis pneumonia (PCP) an...
Failure of sulfa or sulfone prophylaxis is associated with mutations in Pneumocystis carinii gene co...
Failure of sulfa or sulfone prophylaxis is associated with mutations in Pneumocystis carinii gene co...
Failure of sulfa or sulfone prophylaxis is associated with mutations in Pneumocystis carinii gene co...
Failure of sulfa or sulfone prophylaxis is associated with mutations in Pneumocystis carinii gene co...
To determine factors associated with mutations in the Pneumocystis carinii dihydropteroate synthase ...
Meta-analysis shows increased risk for DHPS mutations in patients exposed to sulfa prophylaxis for P...
Pneumocystis pneumonia (PCP) remains a major cause of illness and death in HIV-infected persons. Sul...
Pneumocystis pneumonia (PCP) remains a major cause of illness and death in HIV-infected persons. Sul...
Pneumocystis pneumonia (PCP) remains a major cause of illness and death in HIV-infected persons. Sul...
To investigate the possible association between different prophylactic sulfa drugs and the genotype ...
To investigate the possible association between different prophylactic sulfa drugs and the genotype ...
© 2017 American Society for Microbiology. All Rights Reserved.Mutations in the dihydropteroate synth...
Mutations in the dihydropteroate synthase (DHPS) gene of Pneumocystis jirovecii are associated with ...
Pneumocystis jirovecii dihydropteroate synthase (DHPS) mutations have been associated with failure o...
Pneumocystis jirovecii is a major opportunistic pathogen that causes Pneumocystis pneumonia (PCP) an...
Failure of sulfa or sulfone prophylaxis is associated with mutations in Pneumocystis carinii gene co...
Failure of sulfa or sulfone prophylaxis is associated with mutations in Pneumocystis carinii gene co...
Failure of sulfa or sulfone prophylaxis is associated with mutations in Pneumocystis carinii gene co...
Failure of sulfa or sulfone prophylaxis is associated with mutations in Pneumocystis carinii gene co...
To determine factors associated with mutations in the Pneumocystis carinii dihydropteroate synthase ...
Meta-analysis shows increased risk for DHPS mutations in patients exposed to sulfa prophylaxis for P...
Pneumocystis pneumonia (PCP) remains a major cause of illness and death in HIV-infected persons. Sul...
Pneumocystis pneumonia (PCP) remains a major cause of illness and death in HIV-infected persons. Sul...
Pneumocystis pneumonia (PCP) remains a major cause of illness and death in HIV-infected persons. Sul...
To investigate the possible association between different prophylactic sulfa drugs and the genotype ...
To investigate the possible association between different prophylactic sulfa drugs and the genotype ...
© 2017 American Society for Microbiology. All Rights Reserved.Mutations in the dihydropteroate synth...
Mutations in the dihydropteroate synthase (DHPS) gene of Pneumocystis jirovecii are associated with ...
Pneumocystis jirovecii dihydropteroate synthase (DHPS) mutations have been associated with failure o...
Pneumocystis jirovecii is a major opportunistic pathogen that causes Pneumocystis pneumonia (PCP) an...