CORRESPONDENCE Tumour necrosis factor-α

therapeutic target for prevention of arrhythmogenesis in the setting of acute myocardial infarction? To the Editor In their recently published elegant article,1 Padfield et al have reported potential cardiovascular effects of tumour necrosis factor α (TNF-α) antagonism in patients with non-ST eleva-tion acute myocardial infarction. In this first in human study, the authors have demonstrated that a single dose of etaner-cept (a TNF-α antagonist) infusion might blunt systemic inflammatory response, but might appear to enhance platelet aggrega