9HESI Committee on Biomarkers Expert Working Group on Cardiac Troponins. Company representation as follows:

We investigated the kinetics of circulating biomarker elevation, specifically correlated with morphology in acute myocardial injury.Male Hanover Wistar rats underwent biomarker and morphologic cardiac evaluation at 0.5 to seventy-two hours after a single subcutaneous isoproterenol adminis-tration (100 or 4000mg/kg). Dose-dependent elevations of serumcardiac troponins I andT (cTnI, cTnT), and heart fatty acid–binding protein (H-FABP) occurred from 0.5 hour, peaked at two to three hours, and declined to baseline by twelve hours (H-FABP) or forty-eight to seventy-two hours (Serum cTns). They were more sensitive in detecting cardiomyocyte damage than other serum biomarkers. The Access 2 platform, an automated chemilumi