Canine, human, and rat plasma insulin responses to galanin administration: species response differences

insulin responses to galanin administration: species response differences. Am. J. Physiol. 266 (Endocrinol. Metab. 29): E612-E617, 1994.-Previous studies demonstrated that por-cine galanin is a potent inhibitor of insulin secretion in many species but fails to alter human insulin secretion. To resolve whether this discrepancy was due to the use of a heterologous peptide or to a true species response difference, we studied the effect of a synthetic replicate of human galanin on glucose-stimulated insulin secretion in rats, dogs, and humans. On administration into rats, human and rat galanin significantly inhibited glucose-induced insulin responses to a similar de-gree. Similarly, porcine and human galanin significantly el-evated canine plasma glucose and inhibited canine plasma insulin responses. In contrast, plasma glucose and insulin responses to glucose administration in humans were unaltere