Thrombosis Complicating Renal Amyloidosis in Dogs

Abstract. Thrombosis, sometimes with infarction, occurred in 20 of 52 dogs with renal amyloidosis. Pulmonary thrombosis was most commonly encountered, although the heart, kidneys, intestine, and other tissues were occasionally affected. Recent thrombi and older, organized thrombi occurred, sometimes in the same animal. The possible role of dehydra-tion, hemoconcentration, hyperfibrinogeneniia, hyperglobulinemia, and clot-promoting factors in producing a hypercoagulable state is discussed. Thrombosis is usually not a primary event; it occurs oftener as a compli-cation of some intrinsic disease or of surgery and has been previously de-scribed in association with renal disease. ADDIS [1] noted venous thrombosis in the human nephrotic syndrome whereas FISHBERC [I41 mentioned that ve-nous or arterial thrombosis might occur. SCHWARZ and KOHN [29] reported a patient with heavy proteinuria in whom cerebral and innominate arterial thrombosis with embolization to more distal vessels occurred. Two nephrotic patients with thrombi were described by ALDRICH [2]; one had thrombosis of the iliac vein and the other, thrombosis of the renal vein