Add to ORKGWerner syndrome is a premature aging disorder characterized by cancer predisposition that is caused by loss of the Werner syndrome protein (WRN) helicase/exonuclease DNA repair pro-tein. Hexavalent chromium is an environmental carcinogen and genotoxicant that is associated with respiratory cancers and induces several forms of DNA damage, including lesions that interfere with DNA replication. Based on the evidence that WRN protein facilitates repair of stalled and collapsed replication forks, we hypothesized that WRN functions in the cellular response to and recovery from Cr(VI)-induced genotoxicity and genomic instability. Here we report that human cells deficient in WRN protein are hypersensitive to Cr(VI) toxicity, and exhibit a delayed r...
Genome instability is a characteristic of cancer and aging, and is a hallmark of the premature aging...
WRN is a RecQ helicase with an associated exonuclease activity important in DNA metabolism, includin...
Telomeres protect the chromosome ends and consist of guanine-rich repeats coated by specialized prot...
Werner Syndrome (WS) is an autosomal recessive disorder characterized by the premature development o...
The Werner syndrome protein (WRN) and chromatin assembly factor 1 (CAF-1) are both involved in the m...
International audienceWerner syndrome is an autosomal recessive human genetic instability and cancer...
Summary: Werner syndrome protein (WRN) is a RecQ enzyme involved in the maintenance of genome integr...
Werner syndrome (WS) is a rare autosomal progeroid disorder caused by a mutation in the gene encodin...
Werner's syndrome (WS) is a rare autosomal recessive disorder that arises as a consequence of mutati...
Werner's syndrome (WS) is a rare autosomal recessive disorder that arises as a consequence of mutati...
Genome instability is a characteristic of cancer and aging, and is a hallmark of the premature aging...
International audienceThe Werner syndrome (WS) protein WRN is unique in possessing a 3' to 5' exonuc...
BACKGROUND: Werner syndrome (WS) results from defects in the RecQ helicase (WRN) and is characterize...
Genome instability is a characteristic of cancer and aging, and is a hallmark of the premature aging...
WRN is a RecQ helicase with an associated exonuclease activity important in DNA metabolism, includin...
Telomeres protect the chromosome ends and consist of guanine-rich repeats coated by specialized prot...
Werner Syndrome (WS) is an autosomal recessive disorder characterized by the premature development o...
The Werner syndrome protein (WRN) and chromatin assembly factor 1 (CAF-1) are both involved in the m...
International audienceWerner syndrome is an autosomal recessive human genetic instability and cancer...
Summary: Werner syndrome protein (WRN) is a RecQ enzyme involved in the maintenance of genome integr...
Werner syndrome (WS) is a rare autosomal progeroid disorder caused by a mutation in the gene encodin...
Werner's syndrome (WS) is a rare autosomal recessive disorder that arises as a consequence of mutati...
Werner's syndrome (WS) is a rare autosomal recessive disorder that arises as a consequence of mutati...
Genome instability is a characteristic of cancer and aging, and is a hallmark of the premature aging...
International audienceThe Werner syndrome (WS) protein WRN is unique in possessing a 3' to 5' exonuc...
BACKGROUND: Werner syndrome (WS) results from defects in the RecQ helicase (WRN) and is characterize...
Genome instability is a characteristic of cancer and aging, and is a hallmark of the premature aging...
WRN is a RecQ helicase with an associated exonuclease activity important in DNA metabolism, includin...
Telomeres protect the chromosome ends and consist of guanine-rich repeats coated by specialized prot...