Journal of Neurology, Neurosurgery, and Psychiatry 1987;50:1148-1152 Post-epileptic headache and migraine

SUMMARY One hundred epileptic patients were questioned about their headaches. Post-ictal head-aches occurred in 51 of these patients and most commonly lasted 6-72 hours. Major seizures were more often associated with post-epileptic headaches than minor attacks. Nine patients in this series of 100 also had migraine: in eight of these nine a typical, albeit a mild, migraine attack was provoked by fits. The post-ictal headache in the 40 epileptics who did not have migraine was accompanied by vomiting in 11 cases, photophobia in 14 cases and vomiting with photophobia in 4 cases. Further-more, post-epileptic headache was accentuated by coughing, bending and sudden head movements and relieved by sleep. It is, therefore, clear that seizures provoke a syndrome similar to the headache phase of migraine in 50 % of epileptics. It is proposed that post-epileptic headache arises intra-cranially and is related to the vasodilatation known to follow seizures. The relationship of post-epileptic headache to migraine is discussed in the light of current ideas on migraine pathogenesis, in particular the vasodilation which accompanies Leao's spreading cortical depression. Little is known about post-epileptic headaches, al-though their occurrence is accepted by patients and doctors. Yet standard works '- on both epilepsy an