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Natural compounds have been studied to substitute synthetic antioxidants. In this study, the anti-oxi-dant activity of 70 % acetone extracts from the Vaccinium oldhami fruit was investigated for utilization as ingredients for the cosmetic and bio-industries. Anti-oxidant activity was determined by determin-ing total polyphenolic content, electron donating ability, nitric oxide (NO) radical scavenging activity, ABTS· cation radical scavenging activity and hydrogen peroxide scavenging activity. The poly-phenolic content of 70 % acetone extracts of the Vaccinium oldhami fruit was 55.972 mg TAE/g. In elec-tron donating activity, 70 % acetone extracts of the Vaccinium oldhami fruit showed an effect of 93.9%, which was similar to BHA effect at a concentration of 500 μg/ml. In the NO radical scavenging abil-ity, 70 % acetone extracts of the Vaccinium oldhami fruit showed 60 % at 500 μg/ml. ABTS·+ cation radi-cal scavenging activity of the Vaccinium oldhami fruit at a concentration of 1000 μg/ml was 75.7%. Also, hydrogen peroxide scavenging activity of 70 % acetone extracts showed 80.8 % at 100 μg/ml, whichwas higher than BHA. In the natural compound market, the most important factors are the abil-ity to obtain high effects of a material in low concentrations and a long-lasting supply. The Vaccinium oldhami fruit can be harvested every year – this fulfills one of the requirements. From these results