© American Society for Clinical Pathology Nodular Lymphocyte Predominant Hodgkin Lymphoma An Immunophenotypic Reappraisal Based on a Single-Institution Experience

A b s t r a c t In our experience, certain commonly cited immunophenotypic features of nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) are not encountered in day-to-day practice. We reviewed 60 cases of NLPHL (18 women, 42 men; median age, 34 years) to discern immunophenotypic features from a large, single-institution cohort. All cases contained lymphocytic and histiocytic (L&H) cells. These cells expressed CD20 in 98 % (59/60), CD79a (usually faint) in 87 % (27/31), CD30 in 7 % (4/59), epithelial membrane antigen in 21 % (12/56), bcl-2 in 5 % (2/41), and bcl-6 in 83 % (30/36) of cases. CD10 was negative in all 36 cases studied; 100 % of cases (55/55) demonstrated CD3+ rosettes. Although CD57+ T cell