The effect of nafazatrom, a new antithrombotic agent, was studied in a canine model of regional myocardial ischemia. Nafazatrom was administered 1 mg/kg intravenously every 6 h for 48 h. After 24 h of drug or placebo administration, animals underwent 90 min of occlusion of the proximal eft circumflex coronary artery followed by gradual reperfusion over a period of 30 min. Twenty-four hours later, the animals were sacrificed and infarct size was determined by histochemical staining with triphenyltetrazolium chloride. Nafazatrom-treated animals had a significant reduction in infarct size expressed as a percent of the anatomical area at risk for infarction: 21 + 5 % in the treated group vs. 41 + 5 % in the control group (X + S.E.M., P < 0.0...
AbstractThe aim of this study was to test the hypothesis that either the cyclooxygenase inhibitor as...
The effects of prostacyclin (PGI2) on infarct size and regional myocardial blood flow were studied i...
SUMMARY The hemodynamic and antithrombotic properties of prostacyclin (PGI2) were evaluated in an in...
The effect of nafazatrom, a new antithrombotic agent, was studied in a canine model of regional myoc...
The effects of nafazatrom on leukocyte function in vitro and in vivo were related to its ability to ...
BW755C is a new antiinflammatory agent which predominantly inhibits lipoxygenase over cyclooxygenase...
Concomitant use of pharmacologie agents may be required for maximal salvage of ischemic myocardium b...
Prostacyclin (PGI$\\sb2$; 50 ng/kg/min) was administered to open chest anesthetized dogs subjected t...
SUMMARY We studied 25 anesthetized and thoracotamized dogs before and during 5 hours of acute region...
The effect of diltiazem vs. saline was studied in a conscious canine model of coronary thrombosis. D...
International audienceTrimetazidine (TMZ) has been described as a new antiischemic agent. Whereas it...
Lidocaine has been shown to protect ischemic myocardium, but the degree of its effectiveness is not ...
Tissue-type plasminogen activator (t-PA) is a widely used thrombolytic agent for treating acute myoc...
Myocardial ischemia reperfusion (I/R) injury contributes to almost half of the necrotic area after m...
SUMMARY We investigated the effect of indomethacin, a widely used nonsteroidal antiinflammatory drug...
AbstractThe aim of this study was to test the hypothesis that either the cyclooxygenase inhibitor as...
The effects of prostacyclin (PGI2) on infarct size and regional myocardial blood flow were studied i...
SUMMARY The hemodynamic and antithrombotic properties of prostacyclin (PGI2) were evaluated in an in...
The effect of nafazatrom, a new antithrombotic agent, was studied in a canine model of regional myoc...
The effects of nafazatrom on leukocyte function in vitro and in vivo were related to its ability to ...
BW755C is a new antiinflammatory agent which predominantly inhibits lipoxygenase over cyclooxygenase...
Concomitant use of pharmacologie agents may be required for maximal salvage of ischemic myocardium b...
Prostacyclin (PGI$\\sb2$; 50 ng/kg/min) was administered to open chest anesthetized dogs subjected t...
SUMMARY We studied 25 anesthetized and thoracotamized dogs before and during 5 hours of acute region...
The effect of diltiazem vs. saline was studied in a conscious canine model of coronary thrombosis. D...
International audienceTrimetazidine (TMZ) has been described as a new antiischemic agent. Whereas it...
Lidocaine has been shown to protect ischemic myocardium, but the degree of its effectiveness is not ...
Tissue-type plasminogen activator (t-PA) is a widely used thrombolytic agent for treating acute myoc...
Myocardial ischemia reperfusion (I/R) injury contributes to almost half of the necrotic area after m...
SUMMARY We investigated the effect of indomethacin, a widely used nonsteroidal antiinflammatory drug...
AbstractThe aim of this study was to test the hypothesis that either the cyclooxygenase inhibitor as...
The effects of prostacyclin (PGI2) on infarct size and regional myocardial blood flow were studied i...
SUMMARY The hemodynamic and antithrombotic properties of prostacyclin (PGI2) were evaluated in an in...