Serum IgD and IgE concentrations in immunodeficiency diseases

measured in sera from 165 patients with well-defined immunodeficiency in an effort to find information pos-sibly relevant to the roles of antibodies of these classes in host defense. Values for both immunoglobulins were generally quite low in patients who had marked defi-ciencies of all three major immunoglobulins, although occasional normal or high normal values for IgD were seen in hypogammaglobulinemic patients. Group mean IgD concentrations were also depressed in patients with Wiskott-Aldrich syndrome and in those with selective IgA deficiency; IgE concentrations were depressed in patients with X-linked immunodeficiency with hyper-IgM and in those with ataxia telangiectasia. IgD and IgE were both significantly elevated in patients with extreme hyperimmunoglobulinemia E and undue susceptibility to infection and in a patient with the Nezelof syndrome; none of these patients had histories suggestive of atopy. In addition, the mean IgE concentration was signifi-cantly elevated in patients with selective IgA deficiency, many of whom were atopic, and in those with the Wis-kott-Aldrich syndrome. The highest IgD concentration (163 mg/100 ml) was found in serum from a boy with variable immunodeficiency who had a lifelong history of severe recurrent pharyngeal infections, primarily streptococcal in etiology. Recurrent staphylococcal in-fection was a feature common to many but not all pa-tients with elevated IgD and IgE. Depressed cell-medi-ated immunity was present in many patients with ele-vated serum IgE concentrations. These data may prove useful in the future delineation of biologic roles for antibodies in these two immunoglobulin classes