RESEARCH ARTICLE Treatment of diabetic mic e

capacity of a wound to heal depends in part on its depth, as well as on the overall health and nutritional Egypt Full list of author information is available at the end of the articleBackground Type I diabetes (T1D) is a chronic autoimmune disease caused by the specific destruction of pancreatic β-cells, which produce insulin [1], Multiple complications are usually associated with diabetes mellitus [2]. Impaired wound healing represents a severe complication of the disease, which could diminish physical activity and lead to chronic wounds and limb amputation [3]. Previous studies have reported that wound healing involves a complex series of interactions between different cell types, cytokine mediators, and the extracellular matrix. The phases of normal wound healing include hemo-stasis, inflammation, proliferation, and remodeling [4]. Moreover, many factors that can affect wound healing interfere with one or more phases in this process, thus causing improper or impaired tissue repair. For instance, collagen deposition in acute wounds is impaired in T1D; possibly due to a decreased fibroblast proliferation [5]