Impact of Common Type 2 Diabetes

OBJECTIVE—The emerging picture of type 2 diabetes genetics involves differently assembled gene variants, each modestly increasing risk with environmental exposure. However, the rel-evance of these genes for disease prediction has not been extensively tested. RESEARCH DESIGN AND METHODS—We analyzed 19 com-mon polymorphisms of 14 known candidate genes for their contribution to prevalence and incidence of glucose intolerance in the DESIR (Data from an Epidemiological Study on the Insulin Resistance syndrome) prospective study of middle-aged Cauca-sian subjects, including 3,877 participants (16.8 % with hypergly-cemia and 7.9 % with diabetes after the 9-year study). RESULTS—The GCK (Glucokinase)30A allele was associated with increased type 2 diabetes risk at the end of the follow-up study (adjusted OR 1.34 [95 % CI 1.07–1.69]) under an additiv