Original article Report of a European consensus workshop to develop

Background: Non-Hodgkin’s lymphoma (NHL) comprises a group of related haematological malig-nancies, predominantly of B-cell origin, which have been described as indolent or aggressive according to their clinical course. Standard treatment for indolent NHL consists of conventional che-motherapy, but, although long-term remissions may occur, most patients will die of their disease. Radioimmunotherapy (RIT) is a novel modality for treating indolent NHL, using monoclonal anti-bodies to target tumour cells with systemic, low-dose radiation. 90Y-Ibritumomab tiuxetan (Zevalinw; Schering AG, Berlin, Germany), the first RIT approved for use in relapsed/refractory indolent NHL, comprises the murine anti-CD20 monoclonal antibody ibritumomab, covalently linked to the high-energy beta-emitter, yttrium-90, by the chelator, tiuxetan. Materials and methods: A multidisciplinary consensus workshop of European clinicians who had taken part in clinical trials of 90Y-ibritumomab tiuxetan was convened to develop recommendations for the clinical preparation and administration of 90Y-ibritumomab tiuxetan in Europe. The work-shop was held in anticipation of European Medicines Agency approval of this agent, which was gained in 2004 for adult patients with rituximab-relapsed or refractory CD20+ follicular B-cell NHL. Results and conclusions: This article summarises the consensus recommendations developed for haemato-oncologists. Key words: guidelines, haematologist, lymphoma, oncologist, 90Y-ibritumomab tiuxeta