Lens epithelium-derived growth factor (LEDGF/p75) tethers lentiviral preintegration complexes (PICs) to chromatin and is essential for effective HIV-1 repli-cation. LEDGF/p75 interactions with lentiviral integrases are well characterized, but the structural basis for how LEDGF/p75 engages chromatin is unknown. We demonstrate that cellular LEDGF/p75 is tightly bound to mononucleosomes (MNs). Our proteomic experiments indicate that this interaction is direct and not mediated by other cellular factors. We determined the solution structure of LEDGF PWWP and monitored binding to the histone H3 tail containing trimethylated Lys36 (H3K36me3) and DNA by NMR. Results reveal two distinct functional interfaces of LEDGF PWWP: a well-defined hydro-phobi...
Lens epithelium-derived growth factor (LEDGF/p75) is a transcriptional co-activator involved in targ...
Lens epithelium-derived growth factor (LEDGF/p75) is a transcriptional co-activator involved in targ...
LEDGF/p75 is a transcriptional coactivator implicated in the pathogenesis of AIDS and leukemia. In t...
Lens epithelium-derived growth factor (LEDGF/p75) tethers lentiviral preintegration complexes (PICs)...
<div><p>PWWP domains are involved in the chromatin attachment of several proteins. They bind to both...
Lens Epithelium Derived Growth Factor/p75 (LEDGF/p75) is a transcriptional co-activator tethering pr...
International audienceLens epithelium-derived growth factor (LEDGF)/p75 functions as a bimodal tethe...
Nearly all cellular and disease related functions of the transcriptional co-activator lens epitheliu...
Lens epithelium-derived growth factor/p75 (LEDGF/ p75) is a transcriptional coactivator involved in ...
LEDGF/p75 is a chromatin-interacting, cellular cofactor of HIV integrase that dictates lentiviral in...
Lens epithelium-derived growth factor p75 (LEDGF/p75), a transcriptional co-activator, plays an impo...
LEDGF/p75 is a chromatin-interacting, cellular cofactor of HIV integrase that dictates lentiviral in...
Integration of human immunodeficiency virus type 1 (HIV-1) displays a strong bias towards active gen...
Lens epithelium-derived growth factor (LEDGF/p75) is a transcriptional co-activator involved in targ...
Lens epithelium-derived growth factor (LEDGF/p75) is a transcriptional co-activator involved in targ...
LEDGF/p75 is a transcriptional coactivator implicated in the pathogenesis of AIDS and leukemia. In t...
Lens epithelium-derived growth factor (LEDGF/p75) tethers lentiviral preintegration complexes (PICs)...
<div><p>PWWP domains are involved in the chromatin attachment of several proteins. They bind to both...
Lens Epithelium Derived Growth Factor/p75 (LEDGF/p75) is a transcriptional co-activator tethering pr...
International audienceLens epithelium-derived growth factor (LEDGF)/p75 functions as a bimodal tethe...
Nearly all cellular and disease related functions of the transcriptional co-activator lens epitheliu...
Lens epithelium-derived growth factor/p75 (LEDGF/ p75) is a transcriptional coactivator involved in ...
LEDGF/p75 is a chromatin-interacting, cellular cofactor of HIV integrase that dictates lentiviral in...
Lens epithelium-derived growth factor p75 (LEDGF/p75), a transcriptional co-activator, plays an impo...
LEDGF/p75 is a chromatin-interacting, cellular cofactor of HIV integrase that dictates lentiviral in...
Integration of human immunodeficiency virus type 1 (HIV-1) displays a strong bias towards active gen...
Lens epithelium-derived growth factor (LEDGF/p75) is a transcriptional co-activator involved in targ...
Lens epithelium-derived growth factor (LEDGF/p75) is a transcriptional co-activator involved in targ...
LEDGF/p75 is a transcriptional coactivator implicated in the pathogenesis of AIDS and leukemia. In t...