Inflammation-Sensitive Plasma Proteins Are Associated With Future Weight Gain

Cross-sectional studies have associated obesity and other components of the so-called metabolic syndrome with low-grade inflammation. The temporal and causal relations of this association have not been fully ex-plored. This study explored whether elevated levels of inflammation-sensitive plasma proteins (ISPs) (fibrin-ogen, orosomucoid, 1-antitrypsin, haptoglobin, and ceruloplasmin) are associated with future weight gain. Five ISPs were measured in 2,821 nondiabetic healthy men (38–50 years of age) who were reexamined after a mean follow-up of 6.1 years. Future weight gain was studied in relation to the number of elevated ISPs (i.e., in the top quartile). The proportion with a large weight gain (75th percentile>3.8 kg) was 21.0, 25.9, 26.8, and 28.3%, respectively, among men with none, one, two