Light inducible protein-protein interactions are powerful tools to manipulate biological processes. Genetically encoded light-gated proteins for controlling precise cellular behavior are a new and promising technology, called optogenetics. Here we exploited the blue light-induced transcription system in yeast and zebrafish, based on the blue light dependent interaction between two plant proteins, blue light photoreceptor Cryptochrome 2 (CRY2) and the bHLH transcription factor CIB1 (CRY-interacting bHLH 1). We demonstrate the utility of this system by inducing rapid transcription suppression and activation in zebrafish
The zebrafish ( Danio rerio) is a powerful vertebrate model to study cellular and developmental proc...
Light serves as a key environmental signal for synchronizing the circadian clock with the day night ...
Light serves as a key environmental signal for synchronizing the circadian clock with the day night ...
Light inducible protein-protein interactions are powerful tools to manipulate biological processes. ...
<p>A. Schematic of split Gal4 modules expressed in zebrafish together with a LUC reporter gene under...
Inducible gene expression systems are an invaluable tool for studying biological processes. Optogene...
Optogenetic gene expression systems can control transcription with spatial and temporal detail unequ...
<p>A. Structure of the G-box–driven LUC reporter gene and DNA sequences of the recombinant G-box (Gw...
Numerous responses are triggered by light in the cell. How the light signal is detected and transduc...
Here, we describe an optogenetic gene expression system optimized for use in zebrafish. This system ...
Most organisms possess circadian clocks that are able to anticipate the day/night cycle and are rese...
Most organisms possess circadian clocks that are able to anticipate the day/night cycle and are rese...
Inducible gene expression systems are valuable tools for studying biological processes. We previousl...
The zebrafish (Danio rerio) is a powerful vertebrate model to study cellular and developmental proce...
Abstract: Inducible gene expression systems are valuable tools for studying biological processes. W...
The zebrafish ( Danio rerio) is a powerful vertebrate model to study cellular and developmental proc...
Light serves as a key environmental signal for synchronizing the circadian clock with the day night ...
Light serves as a key environmental signal for synchronizing the circadian clock with the day night ...
Light inducible protein-protein interactions are powerful tools to manipulate biological processes. ...
<p>A. Schematic of split Gal4 modules expressed in zebrafish together with a LUC reporter gene under...
Inducible gene expression systems are an invaluable tool for studying biological processes. Optogene...
Optogenetic gene expression systems can control transcription with spatial and temporal detail unequ...
<p>A. Structure of the G-box–driven LUC reporter gene and DNA sequences of the recombinant G-box (Gw...
Numerous responses are triggered by light in the cell. How the light signal is detected and transduc...
Here, we describe an optogenetic gene expression system optimized for use in zebrafish. This system ...
Most organisms possess circadian clocks that are able to anticipate the day/night cycle and are rese...
Most organisms possess circadian clocks that are able to anticipate the day/night cycle and are rese...
Inducible gene expression systems are valuable tools for studying biological processes. We previousl...
The zebrafish (Danio rerio) is a powerful vertebrate model to study cellular and developmental proce...
Abstract: Inducible gene expression systems are valuable tools for studying biological processes. W...
The zebrafish ( Danio rerio) is a powerful vertebrate model to study cellular and developmental proc...
Light serves as a key environmental signal for synchronizing the circadian clock with the day night ...
Light serves as a key environmental signal for synchronizing the circadian clock with the day night ...