STUDY OF GENETIC BY ENVIRONMENTAL INTERACTIONS AT TRANSCRIPTOMIC AND GENOMIC LEVELS BY

Many phenotypes in humans and animals are resulted by the interaction between genes and environment. For example, animals from distinct breeds may have different nutritional requirements, and thus, may respond in a particular way for each diet. In a similar fashion, genetic variability in the human population is responsible for the difference in drug efficiency on the treatment of several diseases. The development of high-throughput genomic and transcriptomics technologies has been providing rapid access to DNA and RNA information in humans and cattle. The access to this genetic characterization is a cornerstone step in understanding the complexity of characteristics within populations of these organisms. In humans, much of the attention on gene by environment interaction is brought for the understanding of several diseases. Glioblastoma multiforme (GBM), a grade IV cancer, is a complex multifactorial disorder that has swift and devastating consequences. With the objective of identifying general and clinical-dependent biomarkers for biomarkers for GBM, the expression pattern of 22,277 probes from 320 individuals diagnosed with GBM was evaluated. Three GBM time-to-event variables were considered: lifetime, overall and progression-fre