Laboratory Confirmation of the Diagnosis of Cystic Fibrosis

The recent commercial introduction of a method for de-tecting albumin in meconium makes screening for cystic fibrosis feasible for many hospitals. If the test is adopted, confirmatory tests should be available. Quantitative analyses of sweat for sodium by flame photometry and for chloride by silver titration and ion-selective electrodes are now used as confirmatory tests. We compare results of these confirmatory methods applied to persons with cystic fibrosis, respiratory disorders, or digestive disorders, and to control subjects. Additional Keyphrases: respiratory disorders #{149}digestive disorders #{149}Na and Cl determination in sweat #{149}albumin in meconium #{149}pediatric chemistry #{149}screening e in-herited disorders #{149}normal values #{149}Na, Ci_, K+ corre-lation