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Objective: Recent studies have demonstrated that various human viruses, especially cy-tomegalovirus (HCMV) and Epstein Barr virus (EBV-1) seem to play a part in the patho-genesis of human periodontitis. The aim of this investigation was to evaluate the subgingi-val presence of HCMV and EBV in patients with aggressive periodontitis (AgP). Materials and Methods: A polymerase chain reaction (PCR) method determined the pre-sence of HCMV and EBV. Subgingival Plaque samples from 26 conductive AgP patients were collected. Results: HCMV was detected in 27 % of AgP patients and EBV-1 in 25 % of AgP patients. HCMV and EBV-1 co-infection was detected in 52 % of AgP patients. Conclusion: These findings indicated that subgingival presence of EBV-1 and HCMV is associated with aggressive periodontitis, and co-infection with HMCV and EBV appears to be particularly deleterious to periodontal health