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ii Comparison of the pharmacokinetic and pharmacodynamic profiles of resveratrol at dietary and pharmacological doses. by Edwina N Scott Epidemiological and preclinical studies suggest that dietary-derived cancer chemopreventive agents may be active at dietary and supra-dietary doses. This project therefore investigated the effect of dose on the pharmacokinetic and pharmacodynamic actions of resveratrol, a polyphenol found in grapes. An achievable dietary intake (5 mg/day in humans) and a supra-dietary dose, previously used in clinical trials, were compared in preclinical systems, in healthy volunteers and in patients. Accelerator mass spectrometry (AMS) was used in the clinical part of this project as its sensitivity allowed the safe administration of radiolabelled resveratrol to participants. In vitro microarray results from human colon HCA7 cancer cells showed that resveratrol exposure for 3 months at 0.01 µM, the estimated plasma level in man afte