Effect of the NSAID Diclofenac on 99mTc-MAG3 and

Renal function and disease are commonly evaluated by ra-dionuclide studies. The choice of radiopharmaceutical agent for various studies is crucial for proper interpretation. 99mTc-mercaptoacetyltriglycine (99mTc-MAG3) is excreted almost exclusively by the renal tubules, whereas 99mTc-diethylenetri-amine pentaacetic acid (99mTc-DTPA) is predominantly ex-creted by glomerular filtration. The present study compared the effect of the nonsteroidal antiinflammatory drug (NSAID) diclofenac, which is the most commonly used drug to relieve kidney pain, on the kinetic behavior of administered 99mTc-MAG3 and 99mTc-DTPA in experimental animals. Methods: Two groups of 12 New Zealand White rabbits (99mTc-MAG3 and 99mTc-DTPA) were used for the renography. Each rabbit served as its own control. The animals were given 60 mL of saline intravenously 30 min before each renographic study.