Is thrombotic microangiopathy a paraneoplastic phenomenon? Case report and review of the literature

It is currently recognized that the pathogenesis of malig-nancy-associated thrombotic microangiopathy (TMA) is distinct from thrombotic thrombocytopenic purpura. This carries important implications in its classification and its management. Here, we report a case of occult malignancy presenting initially as acute kidney injury secondary to TMA and highlight the importance of considering an underlying malignancy in patients not responding to con-ventional therapy for TMA