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Purpose: To evaluate the changes in peripheral refraction profiles associated with myopia progression and treatment modalities used in the Cambridge Anti-Myopia Study. Methods: One hundred and seventy seven myopes in the age range of 14-22 years were enrolled in the study. The mean spherical equivalent refractive error was-3.12 ± 1.87 D and the refractive error of each participant was corrected with contact lenses. The participants were randomly assigned to one of four treatment groups, which included: altered spherical aberration and vision training, altered spherical aberration only, vision training only and control. Peripheral refractive error was measured using an open field autorefractor in the central 60 degrees of the retina in 10 degree steps. The refractive error was measured using cycloplegic auto-refraction. Two year refractive progression data and initial peripheral refraction measurements were available in 113 participants. Measurements of peripheral refraction and cycloplegic refraction were obtained at 3 visits over 2 years in 12-month intervals for 92 participants. Results: All subjects showed a relative peripheral hyperopia, especially in the nasal retina. A limited magnitude of myopia progression of-0.34 ± 0.36D over 2yrs was found in each of the