EVALUATION OF MUTAGENIC EFFECT ȍANTIMUTAGENICȎ OF DALBERGIA LATIFOLIA ON SWISS ALBINO MICE

Dalbergia latifolia Roxb (Family: Fabaceae) is a traditional herb, contain latinone and dalcriodain flavonoid having excellence medicinal value [8]. The present study was designed to evaluate the antimutagenic potential of methanolic extract of D. latifolia, using micronucleus (MN) and chromosomal aberration (CA) assay in mice bone marrow. The antimutagenic effect of D. latifolia was assessed using cyclophosphamide MN formation and CA in mice. The animals were pre-treated with the methanolic extract of D. latifolia orally at two doses of 100, 200 mg/kg body weight for 7 days. In MN and CA test the two doses provided protection when given 24 hrs prior to a single i.p. administration of cyclophosphamide (100 mg/kg body weight). These results demonstrate that methanolic extract of D. latifolia has got anti-mutagenic potential