Neurological Dysfunction and Hyperactive Behavior Associated with Antiphospholipid Antibodies A Mouse Model

Antiphospholipid antibodies (aPL) have been associated with various neurological manifestations, but the underly-ing mechanism has not been elucidated. We assessed mice with induced experimental antiphospholipid syndrome (APS) for neurological and behavioral changes. After immuniza-tion with monoclonal human anticardiolipin antibody (H-3), female BALB/c mice developed elevated levels of circulating anti–negatively charged phospholipids (aPL), anti–