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cell reprogramming of fibroblasts to induced pluripo-to promote DNA looping and thereby facilitate long-distancea common set of ‘‘core’ ’ stem cell-specific transcription factors, namely Oct4, Sox2, and Nanog (Jaenisch and Young, 2008). These activators, in turn, collaborate with both ubiquitous and conjunction with special activators such as Oct4 and Sox2 to regulate transcription of a large number of genes, including Nanog, that form the molecular basis of pluripotency (Gaocell type-specific transcription factors to orchestrate complex gene expression programs that confer upon stem cells the et al., 2008; Kagey et al., 2010; Kidder et al., 2009; Tutter et al., 2009). The transcription of Nanog is exquisitely dependent ontent stem (iPS) cells. This study identifies a tran-scriptional coactivator with diversified functions in maintaining ES cell pluripotency and safeguarding genome integrity