IN

Nifedipine has been shown to be an effective and a well tolerated medication for the treatment of several cardiova-scular diseases. Its low water solubility, however, leads to poor drug absorption from oral dosage forms while commercia-lly available soft capsules lead to a short half- life. In this study a method was developed to prepare contro-l led release nifedipine tablets which would release the drug quickly and sustain the release for a longer period of time. Solid dispersions of nifedipine with polyvinylpyrrolidone (40T) and polyethylene glycol 8000 were prepared to enhance dissolution and microporous polypropylene containing 75% void space was used to control the release to a desired level. Various ratios of the two polymers were used. Th