Add to ORKGA genome-wide association study identified interferon-related de-velopment regulator–1 (IFRD1), a protein expressed by neutrophils, as a key modifier gene in cystic fibrosis (CF) lung disease. Here, we investigated the expression and regulation of IFRD1 in CF neutro-phils. IFRD1 expression was quantified in peripheral blood and air-way neutrophils from patients with CF, patients with non-CF lung disease, and healthy control subjects. The regulation of IFRD1 expressionwas analyzed using isolated neutrophils and ex vivo stim-ulation assays with CF airway fluids. IFRD1 single-nucleotide poly-morphisms (SNPs) were analyzed in a CF cohort (n 572) and correlated with longitudinal lung function and IFRD1 expression
Cystic fibrosis (CF) is the commonest lethal genetic condition affecting Caucasians, arising from a ...
Abstract Background Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane...
Cystic fibrosis (CF) is caused by mutations to the CF transmembraneconductance regulator (CFTR) gene...
A genome-wide association study identified interferon-related development regulator-1 (IFRD1), a pro...
Lung disease is the major cause of morbidity and mortality in cystic fibrosis, an autosomal recessiv...
Nasal polyposis (NP) is an inflammatory disease of the upper nasal airways frequently present in CF ...
Aim of the study was to analyse IFRD1 gene as a possible modifier gene for Cystic Fibrosis Lung Dise...
In seeking more specific biomarkers of the cystic fibrosis (CF) lung inflammatory disease that would...
AbstractThe pathological hallmark of cystic fibrosis (CF) chronic inflammatory response is the massi...
In seeking more specific biomarkers of the cystic fibrosis (CF) lung inflammatory disease that would...
International audienceCystic fibrosis (CF) is a rare genetic disease that affects the respiratory an...
<div><p>Cystic Fibrosis (CF) is the most common monogenic disease among people of Western European d...
Cystic fibrosis (CF) is a rare genetic disease that affects the respiratory and digestive systems. L...
Cystic fibrosis (CF) is a monogenic syndrome determined by over 2000 mutations in the CF Transmembra...
Cystic Fibrosis (CF) is the most common monogenic disease among people of Western European descent a...
Cystic fibrosis (CF) is the commonest lethal genetic condition affecting Caucasians, arising from a ...
Abstract Background Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane...
Cystic fibrosis (CF) is caused by mutations to the CF transmembraneconductance regulator (CFTR) gene...
A genome-wide association study identified interferon-related development regulator-1 (IFRD1), a pro...
Lung disease is the major cause of morbidity and mortality in cystic fibrosis, an autosomal recessiv...
Nasal polyposis (NP) is an inflammatory disease of the upper nasal airways frequently present in CF ...
Aim of the study was to analyse IFRD1 gene as a possible modifier gene for Cystic Fibrosis Lung Dise...
In seeking more specific biomarkers of the cystic fibrosis (CF) lung inflammatory disease that would...
AbstractThe pathological hallmark of cystic fibrosis (CF) chronic inflammatory response is the massi...
In seeking more specific biomarkers of the cystic fibrosis (CF) lung inflammatory disease that would...
International audienceCystic fibrosis (CF) is a rare genetic disease that affects the respiratory an...
<div><p>Cystic Fibrosis (CF) is the most common monogenic disease among people of Western European d...
Cystic fibrosis (CF) is a rare genetic disease that affects the respiratory and digestive systems. L...
Cystic fibrosis (CF) is a monogenic syndrome determined by over 2000 mutations in the CF Transmembra...
Cystic Fibrosis (CF) is the most common monogenic disease among people of Western European descent a...
Cystic fibrosis (CF) is the commonest lethal genetic condition affecting Caucasians, arising from a ...
Abstract Background Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane...
Cystic fibrosis (CF) is caused by mutations to the CF transmembraneconductance regulator (CFTR) gene...