Acute and Sub Acute Toxicity Study on Siddha Drug Mandoora chooranam

Mandoora chooranam(MC) has been used for treatment of Iron deficiency anaemia (IDA)which is a herbo-mineral formulation. As a mandate,steps were taken to evaluate safety profile of MC in rats following OECD guidelines. Acute toxicity studies were done on female wistar albino rat under OECD guidelines 423 and 28 days repeated oral toxicity studies were done on both sexof wistar albino rats under OECD guidelines 407.Acute toxicity studies, MCwas administered single oral dose and observed for 14 days. In Acute toxicity studies no toxic effects were observed upto the dose level of 2000mg/kg body weight.Sub-acute toxicity studies were carried in four different groups in which MC was administrated orally to rats once daily for 28 days in various dosesranging from 40, 200,400 mg/kg for rat respectively. Detailed hematological, biochemical, necropsy and histopathological evaluation of organs was performed for all animals. No toxic effect was observed upto 400mg/kg in sub-acute toxicity studies of Mandoora chooranam