Effects of Metformin on Body Weight and Body Composition in Obese Insulin-Resistant Children A Randomized Clinical Trial

OBJECTIVE—Metformin can decrease adiposity and ameliorate obesity-related comorbid conditions, including abnormalities in glucose homeostasis in adolescents, but there are few data evaluating the efficacy of metformin among younger children. Our objective was to determine whether metformin treatment causes weight loss and improves obesity-related comorbidities in obese children, who are insulin-resistant. RESEARCH DESIGN AND METHODS—This study was a ran-domized double-blind placebo-controlled trial consisting of 100 severely obese (mean BMI 34.6 6 6.6 kg/m2) insulin-resistant children aged 6–12 years, randomized to 1,000 mg metformin (n = 53) or placebo (n = 47) twice daily for 6 months, followed by open-label metformin treatment for 6 months. All children and their parents participated in a monthly dietitian-administered weight-reduction program. RESULTS—Eighty-five percent completed the 6-month random-ized phase. Children prescribed metformin had significantly greater decreases in BMI (difference 21.09 kg/m2, CI 21.87 to 20.31, P = 0.006), body weight (difference23.38 kg, CI25.2 to2 1.57, P, 0.001), BMI Z score (difference between metformin and placebo groups 20.07, CI 20.12 to 20.01, P = 0.02), and fat mass (difference 21.40 kg, CI 22.74 to 20.06, P = 0.04). Fasting plasma glucose (P = 0.007) and homeostasis model assessment (HOMA) insulin resistance index (P = 0.006) also improved more in metformin-treated children than in placebo-treated children. Gastrointestinal symptoms were significantly more prevalent in metformin-treated children, which limited maximal tolerated dos-age in 17%. During the 6-month open-label phase, children treated previously with placebo decreased their BMI Z score; those trea-ted continuously with metformin did not significantly change BMI Z score further. CONCLUSIONS—Metformin had modest but favorable effects on body weight, body composition, and glucose homeostasis in obese insulin-resistant children participating in a low-intensit