Pathogenesis of enteric diseases

ABSTRACT The pathogenesis of digestive disease in poultry involves the cellular events and reactions that result in a deviation from normal structure and function. To a degree, the differentiation of disease and normal in commercial poultry also involves an economic perspec-tive. Factors external to the digestive tract may mimic digestive disease, including reductions in the density of various nutrients and feed refusal. Antinutritional factors, such as certain storage polysaccharides and proteins, are inaccessible to endogenous enzymes and are either indigestible or act as blockers of the digestion of other nutrients. Changes in digestive secretions that result in either excess or deficiency also influence digestive structure and function. Infectious agents and toxins that cause degeneration and necrosis are espe-cially injurious because a series of critical repair events must occur in order to regain function. The conse-quences range from lethal injury of the host animal to diminished performance. The digestive tract has a large component of lymphoid tissue and impairment of the immune system influences the course of protozoan, bacterial and viral enteric diseases