Induction of Hamster Hepatic Peroxisomal β-oxidation and Peroxisome Proliferation-associated 80000 mol. wt. Polypeptide by Hypolipidemic Drugs

chloro-6-(2,3-xylidino)-2-pyrimidinylthio(-β-hydroxyethyl) acetamide]), methyl clofenapate (2-methyl-2[4-(-chlorophenyl)phenoxy]2-methyl-propionate), and clofibrate (ethyl α--chloro-phenoxyisobutyrate) on plasma triglyceride levels, hepatic peroxisome proliferation and peroxisome-associated enzymes in hamsters were investigated. 2 Fenofibrate, pyrinixil and methyl clofenapate were administered in the diet at 0.2 % level (w/w) for 6 weeks. Clofibrate was fed at 0.5 % level. 3 Fenofibrate, pyrinixil and methyl clofenapate induced a marked prolifera-tion of peroxisomes in hamster liver cells which was comparable to that observed in the rat and mouse liver, whereas the peroxisome proliferative effect of clofibrate was less pronounced. Peroxisomal fatty acid β-oxidation system was found in the hamster liver and its activity was enhanced signific-antly by hypolipidemic drugs. The magnitude of induction of [1-14C]palmitoyl CoA oxidation, heat-labile enoyl-CoA hydratase and peroxisome proliferation-associated 80000 mol. wt. polypeptide in the hamster appeare