Detection of Amphetamine Following Administration of

I Abstract] Drugs that are metabolized to amphetamine or methamphetamine are potentially significant concerns inthe interpretation of amphetamine-positive drug testing results. A number of different compounds have been reported to produce amphetamine in the urine of users. One of these compounds, fenproporex, has been shown to produce amphetamine. Previous reports indicate th the parent compound can bedetected only for a few hours following administration, whereas the amphetamine can be detected for several days. Administration of fenproporex to five healthy volunteers resulted in amphetamine being detected in the urine of all subjects. Peak concentrations of amphetamine were detected at approximately 6-20 h postdose and ranged from approximately 1200 to 2100 ng/mL amphetamine. Amphetamine could be detected (>5 ng/mL) in the urine for up to 119 h. Analysis of th