Chitosan:Vitamin C Containing Hydrogels as a Prototype Functional Prolonged Pain Management Restorative Material In-Vitro Studies

Restorative materials in the new era aim to be “bio-active ” and long-lasting. As a part of our con-tinuous interest of developing functional dual action restorative materials capable of being “bio-active ” and wound healing, we design and evaluate several novel chitosan-vitamin C (5:1) con-taining hydrogels as a prototype of host:guest molecular free radical defense material containing hydroethanoic propolis extract (antioxidant containing material), naproxen, ibuprofen (non ste-roidal anti-inflammatory medication), or aspirin (pain relieve medication and free radical sca-vengers) as functional restorative materials. We will evaluate the physical properties, bonding to dentin as well as test the bioadhesion of the newly designed materials in order to access the suita-bility of these prototype materials as suitable restorative materials. Materials and Methods: The hydrogels were prepared by previously reported by us protocol. The physico-chemical feature