Add to ORKGBACKGROUND: MicroRNAs (miRs) are a class of small noncoding RNAs whose expression changes have been associated with cancer development and progression. Current techniques to isolatemiRs for expression anal-ysis fromblood are inefficient.We developed a reverse-transcription quantitative real-time PCR (RT-qPCR) assay for direct detection of circulating miRs in serum. We hypothesized that serum concentrations of miR-21, a biomarker increased in breast tumors, would cor-relate with the presence and extent of breast cancer. METHODS: The RT-qPCR applied directly in serum (RT-qPCR-DS) assay for circulatingmiR-21was tested in sera from 102 patients with different stages of breast cancer and 20 healthy female donors. RESULTS: The assay was sensitive...
To date, there are no highly sensitive and specific minimally invasive biomarkers for detection of b...
Background: One major impediment to improving the management of breast cancer is the current lack of...
Introduction: MicroRNAs (miRs) are interesting new diagnostic targets that may provide important ins...
Novel, non-invasive biomarkers to diagnose breast cancer with high sensitivity and specificity are g...
MicroRNA-21 (miR-21) was reported as being overexpressed in various human cancerous tissues, but its...
Although a lot of hard work against cancer to reduces its spread but it still continues to kill with...
MicroRNAs (microRNAs) are short sequences of RNA (about 22 nucleotides) that are involved in the reg...
INTRODUCTION: MicroRNAs (miRNAs, miRs) are a class of small, non-coding RNA molecules with relevance...
To date, there are no highly sensitive and specific minimally invasive biomarkers for detection of b...
We previously showed microRNAs (miRNAs) in plasma are potential biomarkers for colorectal cancer det...
Cancer is a major cause of death worldwide. Patients diagnosed at an early stage have an improved pr...
Introduction MicroRNAs (miRNAs, miRs) are a class of small, non-coding RNA molecules with relevance ...
Background: To date, there are no highly sensitive and specific minimally invasive biomarkers for de...
Breast cancer is a complex disease displaying different profiles involving genetic as well as epigen...
Objective: MicroRNA-21. (miR-21) has been shown to be a key regulator of carcinogenesis. There were ...
To date, there are no highly sensitive and specific minimally invasive biomarkers for detection of b...
Background: One major impediment to improving the management of breast cancer is the current lack of...
Introduction: MicroRNAs (miRs) are interesting new diagnostic targets that may provide important ins...
Novel, non-invasive biomarkers to diagnose breast cancer with high sensitivity and specificity are g...
MicroRNA-21 (miR-21) was reported as being overexpressed in various human cancerous tissues, but its...
Although a lot of hard work against cancer to reduces its spread but it still continues to kill with...
MicroRNAs (microRNAs) are short sequences of RNA (about 22 nucleotides) that are involved in the reg...
INTRODUCTION: MicroRNAs (miRNAs, miRs) are a class of small, non-coding RNA molecules with relevance...
To date, there are no highly sensitive and specific minimally invasive biomarkers for detection of b...
We previously showed microRNAs (miRNAs) in plasma are potential biomarkers for colorectal cancer det...
Cancer is a major cause of death worldwide. Patients diagnosed at an early stage have an improved pr...
Introduction MicroRNAs (miRNAs, miRs) are a class of small, non-coding RNA molecules with relevance ...
Background: To date, there are no highly sensitive and specific minimally invasive biomarkers for de...
Breast cancer is a complex disease displaying different profiles involving genetic as well as epigen...
Objective: MicroRNA-21. (miR-21) has been shown to be a key regulator of carcinogenesis. There were ...
To date, there are no highly sensitive and specific minimally invasive biomarkers for detection of b...
Background: One major impediment to improving the management of breast cancer is the current lack of...
Introduction: MicroRNAs (miRs) are interesting new diagnostic targets that may provide important ins...