The Role of the Pulmonary Afferent Receptors in Producing Hemodynamic Changes during Hyperinflation and Endotracheal Suctioning in an Oleic Acid–Injured Animal Model of Acute Respiratory Failure

The purpose of this study was to examine the role of the pulmonary afferent receptors in producing hemo-dynamic changes during hyperinflation and endotra-cheal suctioning (ETS) in an oleic acid–injured animal model of acute respiratory failure. Previous investiga-tions of hyperinflation as a method to prevent hypoxia-induced sequelae of ETS have demonstrated unrecognized hemodynamic consequences. In this within-subject, repeated-measures study, instru-mented, oleic acid–injured dogs had continuous meas-urements of heart rate (HR), mean aortic blood pres-sure (MAP), left ventricular pressure (Plv), pulmonary artery pressure (Ppa), right ventricular afterload (Ppa(tm)), right atrial pressure (Pra), and right ven-tricular filling pressure (Pra(tm)) during hyperinfla