Carmen García-Ruiz

Comparison of charged cyclodextrin derivatives for thechiral separationof atropisomericpolychlorinated biphenyls by capillary electrophoresis Charged cyclodextrin (CD) derivatives were used as chiral selectors in electrokinetic chromatography (EKC) for the chiral separation of highlyhydrophobic neutral racemates such as atropisomeric polychlorinated biphenyls (PCBs). -CD-phosphated, -CD sul-fated, succinylated--CD (Succ--CD) and succinylated--CD (Succ--CD) were used as anionic CDs. As cationic CD, 6-monodeoxy-6-monoamino--CD (-CD-NH2) was tested for the first time in order to separate PCBs. From the different CD derivatives employed, the best separations were obtained with the cationic CD derivative. Thus, the use of -CD-NH2 in phosphate buffer at pH 2.0 containing urea allowed the chira