Add to ORKGTopoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge
It has long been known that type II topoisomerases require divalent metal ions in order to cleave DN...
ABSTRACT: Coordination between the N-terminal gate and the catalytic core of topoisomerase II allows...
Topoisomerase IV is an enzyme that exclusively presents in prokaryotic cells and is mainly responsib...
Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge
ABSTRACT: Although quinolones have been in clinical use for decades, the mechanism underlying drug a...
Quinolones, which target gyrase and topoisomerase IV, are the most widely prescribed antibacterials ...
Catalysis of Type II topoisomerase employs a combination of nucleobase and divalent metal ions with ...
The maintenance of DNA supercoiling is essential for the proper regulation of a plethora of biologic...
The present review focuses on the structural modifications responsible for the transformation of an ...
Type II topoisomerases alter DNA topology by forming a covalent DNA-cleavage complex that allows DNA...
Quinolone antibacterials have been used to treat bacterial infections for over 40 years. A crystal s...
Escherichia coli topoisomerase I (EcTopoI) is a type IA bacterial topoisomerase which is receiving l...
none5siType II topoisomerase (topoII) is a metalloenzyme targeted by clinical antibiotics and antica...
It has long been known that type II topoisomerases require divalent metal ions in order to cleave DN...
Abstract: Quinolones constitute a large class of antibacterial agents whose action is mediated thro...
It has long been known that type II topoisomerases require divalent metal ions in order to cleave DN...
ABSTRACT: Coordination between the N-terminal gate and the catalytic core of topoisomerase II allows...
Topoisomerase IV is an enzyme that exclusively presents in prokaryotic cells and is mainly responsib...
Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge
ABSTRACT: Although quinolones have been in clinical use for decades, the mechanism underlying drug a...
Quinolones, which target gyrase and topoisomerase IV, are the most widely prescribed antibacterials ...
Catalysis of Type II topoisomerase employs a combination of nucleobase and divalent metal ions with ...
The maintenance of DNA supercoiling is essential for the proper regulation of a plethora of biologic...
The present review focuses on the structural modifications responsible for the transformation of an ...
Type II topoisomerases alter DNA topology by forming a covalent DNA-cleavage complex that allows DNA...
Quinolone antibacterials have been used to treat bacterial infections for over 40 years. A crystal s...
Escherichia coli topoisomerase I (EcTopoI) is a type IA bacterial topoisomerase which is receiving l...
none5siType II topoisomerase (topoII) is a metalloenzyme targeted by clinical antibiotics and antica...
It has long been known that type II topoisomerases require divalent metal ions in order to cleave DN...
Abstract: Quinolones constitute a large class of antibacterial agents whose action is mediated thro...
It has long been known that type II topoisomerases require divalent metal ions in order to cleave DN...
ABSTRACT: Coordination between the N-terminal gate and the catalytic core of topoisomerase II allows...
Topoisomerase IV is an enzyme that exclusively presents in prokaryotic cells and is mainly responsib...